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Now Enrolling

Research of a new investigational drug for patients with thyroid eye disease (TED)

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Patients with TED may be living with unmet medical needs.

It’s time to explore more options.

Interleukin-6 (IL-6) is known to be elevated in patients with TED1 and has been implicated in disease pathogenesis.

The spiriTED study is researching TOUR006, an investigational fully human anti-IL-6 monoclonal antibody, in patients with moderate to severe active TED.

The spiriTED study is evaluating the efficacy and safety of 2 different doses of TOUR006 compared with placebo in patients with moderate to severe active TED. The dosing schedule under investigation is a subcutaneous administration every 8 weeks for a total of 3 injections, intended to evaluate the efficacy of TOUR006 while minimizing the drug administration burden for participants and logistical complexity for healthcare professionals.

TOUR006 is under investigation and has not yet been approved, and the safety and effectiveness have not been established.

References
  1. Molnar I, Balazs C. High circulating IL-6 level in Graves’ ophthalmopathy. Autoimmunity. 1997; 25(2):91-96.

Who can participate in this study?

Patients who meet the following criteria may qualify.

  • 18 to 80 years of age (inclusive)
  • Have a clinical diagnosis of Graves’ disease
  • Have moderate to severe symptoms of active TED (not sight-threatening but has an appreciable impact on daily life), usually associated with one or more of the following: lid retraction ≥2 mm, moderate or severe soft tissue involvement, proptosis (exophthalmos), and/or inconstant or constant diplopia
  • Onset of active TED symptoms within approximately 15 months

This is not a complete list of eligibility criteria. Click the button for more information on eligibility criteria.

Full Eligibility Criteria

Study Summary

Study Drug:

TOUR006

Participant Details:

18 to 80 years of age (inclusive) with TED

Sponsor:

Enrollment Period:

Currently Enrolling

Study Site Locations

Click on the map below to see study site locations near you.

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